This issue gathers work on the genomic and epigenomic drivers of carcinogenesis, from the mechanisms that let a cell escape its constraints to the computational methods that let us watch them do it. Original research sits alongside methodological papers, and every article is free to read from the day it appears.

The issue is organised around three threads. Discovery covers tumour evolution, epigenetic regulation and structural variation, including single-cell and spatial approaches to heterogeneity. Translation takes in biomarkers, liquid biopsy and mechanisms of acquired treatment resistance. Methods covers benchmarking studies and analytical tooling released with documented, runnable code.

All articles are published under a Creative Commons licence with no article processing charges. Data and code are deposited as a condition of acceptance, so every figure in this issue can be reproduced from its source.