CRISPR Screens Reveal Synthetic-Lethal Targets in KRAS-Mutant Tumours
Document Type : Original Article
Author
School of Biological Sciences
Abstract
KRAS-mutant cancers remain difficult to treat. We performed genome-wide CRISPR knockout screens across 28 KRAS-mutant tumour models to map synthetic-lethal interactions. Dependencies clustered by tissue of origin rather than KRAS allele, and SHOC2 loss was selectively lethal across pancreatic models irrespective of downstream pathway configuration.
Keywords
Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 147-160
| Article View | 629 |
| PDF Download | 183 |